Diffuse, neuritic, dense core, fibrillary, primitive, compact, burned-out, cotton wool, fleecy, lakes -all ways to describe the morphologies of amyloid beta, the plaque-forming pathologic protein of Alzheimer's disease, in the brain.
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| 200X HE/LFB. Case with severe Alzheimer's pathology with back-to-back amyloid plaques comprising the majority of the field. These dense, pink, fluffy spherical aggregates are surrounded by islands of vacuolated brain tissue with significant reactive astrocytosis (cells with plump, bright pink cytoplasm and visible processes). |
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